Abstracts for Invited Speakers

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Structural Studies of Model Metalloprotein Maquettes Vectorially Oriented at a Soft Interface
J. Kent Blasie
University of Pennsylvania, Philadelphia, Pennsylvania, USA

Whither Biological XAFS?
Grant Bunker
Biophysics Collaborative Access Team, Illinois Institute of Technology, Chicago, Illinois, USA

Biophysics and Synchrotron Radiation: When the Marriage Fails
Martin Caffrey
The Ohio State University, Columbus, Ohio, USA

Diffraction Enhanced X-ray Imaging
Dean Chapman
Illinois Institute of Technology, Chicago, Illinois, USA

X-ray Spectroscopy of Metal Sites in Proteins
Stephen P. Cramer
Lawrence Berkeley National Laboratory, Berkely, California, USA, and UC Davis

Intravenous Coronary Angiography with Synchrotron Radiation: Experience in 366 Patients
W. R. Dix
HASYLAB at DESY, Notkestrasse, Hamburg, Germany

Spectroscopies: Chairman's Introductory Remarks
Barry Dobson
Daresbury Laboratory, Warrington, UK

A Pixel Array Detector for Time-resolved X-ray Diffraction
Eric F. Eikenberry
Robert Wood Johnson Medical Schoool, Piscataway, New Jersey, USA

Anomalous Dispersion and the Phase Problem in Biocrystallography
R. Fourme
LURE, Université Paris-Sud, Orsay, France

Cryocrystallography: Present Highlights and Future Prospects
Elspeth Garman
University of Oxford, UK

Crystallographic and XAFS Studies of Copper Proteins
S. Samar Hasnain
CCLRC Daresbury Laboratory, Warrington, UK

Synchrotron Radiation Protein Crystallography in the Genomics Era
J. R. Helliwell
Department of Chemistry, University of Manchester, Manchester, UK

Advances in Macromolecular Structure Determination
Wayne A. Hendrickson
Columbia University , New York, New York, USA, and the Howard Hughes Medical Institute

The Evolution of Synchrotron Radiation as a Key Enabling Technology in Structural Biology and Biophysics
Keith Hodgson
Stanford University and the Stanford Synchrotron Radiation Laboratory, Stanford, California, USA

Synchrotron Radiation and Muscle Contraction
Kenneth C. Holmes
Max Planck Institute for Medical Research, Heidelberg, Germany

Time-resolved Techniques for Muscle Diffraction with Synchrotron Radiation
Hugh Huxley
Brandeis University, Waltham, Massachusetts, USA

Cryo Samples with a Scanning Transmission X-ray Microscope: Imaging, Tomography, and Spectromicroscopy
C. Jacobsen
SUNY, Stony Brook, New York, USA

The Structure and Dynamics of Protein and Nucleoprotein Assemblies Determined with Synchrotron X-ray Radiation
John E. Johnson
The Scripps Research Institute, La Jolla, California, USA

Macromolecular Complexes: The Frontier with Cell Biology: Chairman's Introductory Remarks
Louise Johnson
University of Oxford, Oxford, UK

Synchrotron Radiation and Industry
Tony Kossiakoff
The University of Chicago, Chicago, Illinois, USA

Crystallographic Analysis of Eukaryotic Signaling Proteins
John Kuriyan
HHMI, The Rockefeller University, New York, New York, USA

High Resolution Soft X-Ray Microscopy of Medically Important Protozoa
Cathleen Magowan
Lawrence Berkeley National Laboratory, Berkeley, California, USA

EGF Receptor Trafficking and Viral Infection Resolved in Live Cells Using Synchrotron Radiation (SR) Microfluorimetry
M. L. Martin-Fernandez
CLRC Daresbury Laboratory, Daresbury, Warrington, UK

Applications of Synchrotron Infrared Microspectroscopy to the Study of Biological Cells and Tissues
Lisa M. Miller
Albert Einstein College of Medicine, Bronx, New York, USA

The Mechanisms of Self-assembly and Polymorphic Switching of the Bacterial Flagellar Filament
Keiichi Namba
International Institute for Advanced Research, Matsushita E.I. Co., Ltd., Seika, Japan

Optics and Special Techniques: Advances and Trends
Glaucius Oliva
The Howard Hughes Medical Institute, University of Sao Paulo, Brazil

Recent Advances in Fluorescence XAFS Using High-brilliance Photon Sources
H. Oyanagi
Electrotechnical Laboratory, Tsukuba, Japan

Bacteriorhodopsin: Crystallography Under Extreme Conditions
Eva Pebay-Peyroula
Institut de Biologie Structurale and Université J.Fourier, Grenoble, France

X-ray Absorption Spectroscopy in the Era of Synchrotron-based Crystallography: Is It obsolete?
James E. Penner-Hahn
The University of Michigan, Ann Arbor, Michigan, USA

X-ray Absorption Spectroscopy of Mn Enzymes
James E. Penner-Hahn
The University of Michigan, Ann Arbor, Michigan, USA

A Fibre Diffraction and Atomic Modeling Study of the Actomyosin Complex
Katrina J. V. Poole
Max Planck Institute for Medical Research, Heidelberg, Germany

Protein Micro-Crystallography at the ESRF Microfocus Beamline
Christian Riekel
European Synchrotron Radiation Facility, Grenoble Cedex, France

Impact of Synchrotron Radiation on Biology and Biophysics
Gerd Rosenbaum
Argonne National Laboratory, Argonne, Illinois, USA

Synchrotron Radiation as a Tool for Investigating Virus Structure: Future Horizons and Past Successes
Michael G. Rossman
Purdue University, West Lafayette, Indiana, USA

Early Days of Biologically Oriented XAS at SSRL
Dale E. Sayers
North Carolina State University, Raleigh, North Carolina, USA

Crystal Structures of Intermediates Occuring along the Reaction Pathway of Cytochrome P450cam
Ilme Schlichting
Max Planck Institute, Dortmund, Germany

X-ray Microscopy: Prospects and Current Developments
Günter Schmahl
University of Göttingen, Göttingsen, Germany

High-resolution X-ray Imaging of Frozen Hydrated Samples in Amplitude and Phase Contrast
G. Schneider
Forschungseinrichtung Roentgenphysik, Georg-August-Universitaet Goettingen, Goettingen, Germany

The Potential of X-ray Free-electron Lasers Based on Superconducting Linear Accelerators
Jochen R. Schneider
HASYLAB at DESY, Hamburg, Germany

Synchrotrons and Biological Complexity: "The Action Is in the Interaction"
Paul B. Sigler
Yale University, New Haven, Connecticut, USA, and the Howard Hughes Medical Institute

The Stereochemistry of Chaperonin Assisted Protein Folding
Paul B. Sigler
Yale University, New Haven, Connecticut, USA

MAD Becoming Sane?
Janet L. Smith
Purdue University, West Lafayette, Indiana, USA

Microbeam Radiation Therapy: Principle and Current Status of Pre-clinical Studies
Per Spanne
European Synchrotron Radiation Facility, Grenoble, France

Nanosecond Time-resolved Macromolecular Crystallography: Probing Photo-initiated Protein Relaxation
Vukica Srajer
The University of Chicago, Chicago, Illinois, USA

Time-resolved Crystallographic Studies of Isocitrate Dehydrogenase Using Intermediate Trapping, Photolytic Triggering, and Synchrotron Radiation
Barry L. Stoddard
The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Structural Studies on a dsRNA Virus
David I. Stuart
University of Oxford, Oxford, UK

Spectroscopy with Synchrotron Radiation: New and Not-So-New
John C. Sutherland
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York, USA

Recent Topics of Synchrotron X-ray Imaging for Medical Research in Japan
Tohoru Takeda
University of Tsukuba, Ibaraki-ken, Japan

Synchrotron Radiation in Research and Clinical Medicine
William Thomlinson
National Synchrotron Light Source, Brookhaven National Laboratory, Upton, New York, USA

Solution Scattering Studies of Protein Conformations and Interactions in Biochemical Regulation
Jill Trewhella
Los Alamos National Laboratory, Los Alamos, New Mexico, USA

Redox-coupled Structural Changes in Bovine Heart Cytochrome c Oxidase
Tomitake Tsukihara
Institute for Protein Research, Osaka University, Suita, Japan

Drug Design Against Shifting Targets: A Structural Basis for Drug Resistance to a Influenza Virus Neuraminidase Variant
Joseph N. Varghese
Biomolecular Research Institute, Parkville, Australia

Structural Dynamics of Actomyosin in Muscle Contraction by X-ray Diffraction/Scattering
Katsuzo Wakabayashi
Osaka University, Osaka, Japan

Structure and Function of Mitochondrial APP Synthase
John Walker
University of Cambridge, Cambridge, UK

The Impact of Synchrotron Radiation on Structural Biology and Biotechnology
Keith D. Watenpaugh
Pharmacia & Upjohn, Inc., Kalamazoo, Michigan, USA

Present State of Experimental Phase Determination by Three-beam Diffraction from Macromolecular Crystals
Edgar Weckert
Universitaet Karlsruhe, Karlsruhe, Germany

Protein Crystal Structures at Atomic Resolution
Keith S Wilson
University of York, York, UK

Picosecond Snapshots of Chemical and Biochemical Reactions Using Pulsed Synchrotron Radiation
Michael Wulff
European Synchrotron Radiation Facility, Grenoble, France

The Design and Prototype of a Detector for Protein Crystallography
Nguyen-Huu Xuong
University of California at San Diego, La Jolla, California, USA; Lawrence Berkeley National Laboratory, Berkeley, California, USA

Crystals of Ribosomes, Exhibiting Severe Non-isomorphism, Extreme Radiation Sensitivity, and No Internal Symmetry, as Subjects for Synchrotron Radiation Crystallography
Ada Yonath
Weizmann Institute, Rehovot and Max-Planck-Research-Unit, Hamburg, Israel

X-ray Absorption Spectroscopy of Mn Enzymes
Eileen Y. Yu
The University of Michigan, Ann Arbor, Michigan, USA

X-ray Microprobe Applications to Life Science
Wenbing Yun
Argonne National Laboratory, Argonne, Illinois, USA

Design and Testing of X-ray Fluorescence Detectors Using Synthetic Multilayers
Ke Zhang
Illinois Institute of Technology, Chicago, Illinois, USA